You are What You Eat—Stanford Study Links Fiber to Anti-Cancer Gene Modulation

The Fiber Gap: A Growing Concern in American Diets

Fiber is well known to be an important part of a healthy diet, yet less than 10% of Americans eat the minimum recommended amount. A new study from Stanford Medicine might finally convince us to fill our plates with beans, nuts, cruciferous veggies, avocados and other fiber-rich foods. The research, which will be published in Nature Metabolism on Jan. 9 identified the direct epigenetic effects of two common byproducts of fiber digestion and found that some of the alterations in gene expression had anti-cancer actions.

When we eat fiber, the gut microbiome produces short-chain fatty acids. These compounds are more than just an energy source for us: They have long been suspected to indirectly affect gene function. The researchers traced how the two most common short-chain fatty acids in our gut, propionate and butyrate, altered gene expression in healthy human cells, in treated and untreated human colon cancer cells, and in mouse intestines. They found direct epigenetic changes at specific genes that regulate cell proliferation and differentiation, along with apoptosis, or pre-programmed cell death processes — all of which are important for disrupting or controlling the unchecked cell growth that underlies cancer.

Linking Fiber and Anti-Cancer Gene Modulation

“We found a direct link between eating fiber and modulation of gene function that has anti-cancer effects, and we think this is likely a global mechanism because the short-chain fatty acids that result from fiber digestion can travel all over the body,” said Michael Snyder, PhD, Stanford W. Ascherman, MD, FACS Professor in Genetics. “It is generally the case that people’s diet is very fiber poor, and that means their microbiome is not being fed properly and cannot make as many short-chain fatty acids as it should. This is not doing our health any favors.”

Synergizing Diet and Cancer Treatments

Given the worrying rates of colon cancer in younger adults, the study findings could also spur conversation and research about the possible synergistic effects of diet and cancer treatment.

“By identifying the gene targets of these important molecules we can understand how fiber exerts its beneficial effects and what goes wrong during cancer,” Snyder added.

Original Publication
Michael Nshanian, Joshua J. Gruber, Benjamin S. Geller, Faye Chleilat, Samuel M. Lancaster, Shannon M. White, Ludmila Alexandrova, Jeannie M. Camarillo, Neil L. Kelleher, Yingming Zhao & Michael P. Snyder
Journal: Nature Metabolism
Article Title: Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression
Article Publication Date: 09 January 2025
DOI: 10.1038/s42255-024-01191-9

Media Contact
Lisa Kim
Stanford Medicine
Email ID: likim@stanfordhealthcare.org
Phone Number (Office): 650-723-6696

Source: EurekAlert!