Complexation with polymeric excipient for improved water solubility
On the one hand, better water solubility of drugs leads to an improved bioavailability. Secondly, drug concentration for application can be decreased.
At Saarland University, a procedure has been developed that allows a significant enhancement of water solubility of compounds that are usually insoluble. The method combines the advantages of both known approaches – without showing their disadvantages. This can be attained by reversible complex formation of the active agents with a certain structural element which is approved for oral application. But simple blending of both components does not lead to an improved solubility. Only a combination of complex formation and freeze drying finally results in products that are water soluble. This approach allows it to produce active agent complexes showing an increased water solubility using standard procedures and prevalent chemicals.
Further Information: PDF
Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
Phone: +49 (0)681/302-6340
Contact
Dr. Annekathrin Seifert (Dipl.-Chem.), Dipl.-Kfm. Axel Koch (MBA), Dr. Hauke Studier (Dipl.-Phys.)
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Pinpointing hydrogen isotopes in titanium hydride nanofilms
Although it is the smallest and lightest atom, hydrogen can have a big impact by infiltrating other materials and affecting their properties, such as superconductivity and metal-insulator-transitions. Now, researchers from…
A new way of entangling light and sound
For a wide variety of emerging quantum technologies, such as secure quantum communications and quantum computing, quantum entanglement is a prerequisite. Scientists at the Max-Planck-Institute for the Science of Light…
Telescope for NASA’s Roman Mission complete, delivered to Goddard
NASA’s Nancy Grace Roman Space Telescope is one giant step closer to unlocking the mysteries of the universe. The mission has now received its final major delivery: the Optical Telescope…