Exosomes – Use of exosomes in prevention and therapy of acute inflammation associated diseases
Exosomes are nano-sized, secreted cell organelles that are released by a huge variety of different cell species, including mesenchymal stem cells (MSCs). Containing a combination of lipids and proteins as well as RNAs, exosomes participate in intercellular communication processes.
Due to the wide range of molecules they enclose and their cell type specific assembly, these small membrane vesicles get more and more in the focus of diagnosis, drug delivery and clinical applications. Some preliminary pre-clinical and clinical application of MSC-derived exosomes of scientists at the University Duisburg-Essen revealed very promising results (see below). However, coupled with the fact that beneficial effects of MSC administration are controversially discussed, it appears very likely that not all MSC-derived exosome fractions will exert beneficial effects. To select for MSC exosomes being able to efficiently suppress inflammation associated symptoms the scientists compared immune modulating activities of independent MSC-derived exosome preparations. Aiming to treat a 22-years female patient suffering from severe therapy-refractory cutaneous and intestinal Graft-versus-Host Disease (GvHD) grade IV with MSC-derived exosomes, the scientists administered exosomes which revealed the strongest immune-suppressive effects in vitro. The documentation of the impacts on the clinical symptoms and the immune response showed that the selected MSC exosome preparation helped to suppress GvHD symptoms in vivo. Since the in vivo administration appears to be safe, MSC exosome administration of selected preparations turned out to be a promising new treatment option in the prevention and therapy of diseases associated with acute inflammatory processes, such as GvHD, stroke, heart-attack and neonatal damages of the brain and lungs.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 10
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
First-of-its-kind study uses remote sensing to monitor plastic debris in rivers and lakes
Remote sensing creates a cost-effective solution to monitoring plastic pollution. A first-of-its-kind study from researchers at the University of Minnesota Twin Cities shows how remote sensing can help monitor and…
Laser-based artificial neuron mimics nerve cell functions at lightning speed
With a processing speed a billion times faster than nature, chip-based laser neuron could help advance AI tasks such as pattern recognition and sequence prediction. Researchers have developed a laser-based…
Optimising the processing of plastic waste
Just one look in the yellow bin reveals a colourful jumble of different types of plastic. However, the purer and more uniform plastic waste is, the easier it is to…