KERatin – 3D artificial skin models for therapy strategies of keratinisation disorders

The present invention describes a 3D model mimicking normal skin. The model shows the following advantages:

– a collagen-fibroblast matrix and a fully stratified and cornified epidermal layer of primary human keratinocytes – epidermal basal layer and terminal differentiation can be seen – barrier function is present (normal skin) or reduced (disease model) – able to mimic single gene caused keratinisation disorders, e.g. congenital ichthyosis Challenge Since European and national regulations restrict the use of animals for the production and development of cosmetic products, adequate skin models are required. Pharmacological and pharmaceutical studies are presently done in 2D cell cultures, rodents and finally in humans. All these test systems either lack the genetic defect and disease phenotype that the drug is intended to cure or have to be developed tediously. Pharmacological and medical outcomes are thereto only predictable, as drug metabolism, drug transfer, e. g. through the epidermis, drug effect (in skin with missing gene products) cannot be foreseen.

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