Method for the Detection of Antigen Presentation

Efficient processing and surface expression of tumor antigens are a prerequisite for successful immune-based cancer therapies. Unfortunately, spatial distribution of antigens is very difficult to determine with standard histological techniques. So cells might harbor tumor antigens inside the cytoplasm, but lack the appropriate MHC I or MHC II presentation on their cell surface. The current invention discloses a simple method to determine MHC-restricted presentation of any antigen of interest on the cell surface.

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DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
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Dr. Ruth Herzog

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