Novel cyclodextrins for hydrophobic drug delivery

Scientists of Saarland University and Julius Maximilian University of Würzburg have developed novel water soluble 6-thioalkyl-cyclodextrins, which form highly stable complexes with APIs. The new cyclodextrins show low ion strength in solution and no pH dependence. They can be obtained in well-defined stoichiometry, no statistic, randomly substituted products are generated, thereby simplifying quality control and analysis. Even highly volatile substances such as the anesthetics halothane or sevoflurane can be complexed. For example, one of the new 6-thioalkyl-cyclodextrins showed the highest binding affinities sevoflurane and halothane, much higher than native cyclodextrins or and known cyclodextrin derivatives.

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