Technology Offerings

Experiments at the University of Bonn have shown that the expression of MED15, a subunit of the trans-criptional co-regulator Mediator, correlates with the proliferative activity of cells. MED15 is essential for TGF-ß-signaling and control of cholesterol/lipid homeostasis. The protein shows low frequency in androgen-sensitive prostate cancer and lacks expression in benign prostatic tissue.

Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulfatase A (ASA). This results in accumulation of sulfated glycosphingolipids, mainly 3-O-sulfogalactosylceramide (sulfatide), in the nervous system and various other organs. In patients, lipid storage causes a progressive loss of myelin leading to various neurological symptoms. The sulfatide storage in ASA-deficient mice is comparable to humans, but the mice do not mimic the myelin pathology.
Therefore, transgenic ASA-deficient (tg/ASA(-/-)) mice were generated overexpressing the sulfatide-synthesizing enzyme galactose-3-O-sulfotransferase.

Tool coils for or magneforming (or electromagnetic forming = EMF) of complex, 3D shaped parts were previously wound from wires or produced by complex
processes such as milling and wire eroding. The milling process is necessary to produce the outer contour. Wire eroding is used to create the winding structures,
whereby it should be noted, that a 3D design is very limited. The invention concerns to special coils
for EM forming and for a method for their production, wherein the current-carrying coil body is additively manufactured using a rapid prototyping method (laser
melting, etc.).

<b>Background</b>
Protein kinase C zeta (PKCζ) is implicated in the development of several inflammatory diseases and a promising therapeutic target. PKCζ controls TH2 response and is important for the regulation of NF-κB transcriptional activity. Moreover, there is increasing evidence for an involvement of PKCζ in tumor development, where it controls chemoresistance and cancer–related inflammation.

<b>Invention</b>
Scientists of Saarland University and German University in Cairo have discovered 1,3,5-trisubstituted and 1,3,4,5-tetrasubstituted pyrazolines as a potent and selective class of allosteric PKCζ inhibitors. Several of the compounds show inhibitory activity in the nanomolar range. The compounds have an allosteric mode of action by binding the less conserved PIF pocked domain and are highly selective for the specific PKC isoform.

<b>Applications</b>
The present technology opens up an innovative therapeutic approach for the treatment of inflammatory diseases in which the identified compounds can serve as starting points for drug development. First experiments indicate relevance particularly for chronic obstructive pulmonary disease (COPD).

<b>Advantages</b>
• Innovative potent small molecules for selective PKCζ inhibition
• Allosteric mode of action increases selectivity
• Highly versatile scaffold for the independent optimization of four substituents
• Specific targeting may contribute to fewer side effects
• Potential treatment of diseases with high unmet medical need

We propose a fundamentally new, direct solution for real-time monocular SLAM/Odometry (VO). The method runs in real-time on a laptop CPU or modern smart phone. In addition to accurate and robust camera-tracking, it estimates precise, semi-dense depth maps.

The invention describes SiC/Graphene Transistors for Normally-On/Normally-Off Operation and Integrated Circuits (Including Logic). This invention can be used, e.g. to
build a compact constant current source for LED-lightning,
include the control circuits and the LED on the same SiC-subtrate and/or provide control circuits for high power switches.