Technology Offerings

pH-biosensors based on compounds with pH-sensitive enolic groups for magnetic resonance imaging and spectroscopy and their uses. Possible medical applications for pH imaging with this new pH sensor are extremely numerous since many pathologies cause changes in pH. Good examples are tumors, inflammation and ischemia. Furthermore, the application as a very precise pH sensor for in vitro NMR-spectroscopy is possible, e.g. for response-to-treatment monitoring of treatments applied to cell lines.

With their broad field of application in basic research, diagnostics and therapy, antibodies represent one of the most important groups of proteins in biotechnology. However, due to their complex folding and assembly, industrial production of antibodies is costly. Consequently, improving antibody properties is of high commercial interest. The present technology here improves antibody´s biophysical properties by introducing two intra-molecular modifications in the antibody structure. This results in an significantlyenhancedstabilityandsecretion.

Protein trans-splicing catalyzed by split inteins is a powerful technique for Assembling a polypeptide backbone from two separate parts. As shown in the figure, the N and C terminal intein fragments associate and fold into the active domain thereby linking the
flanking sequences with a peptide bond. However, split inteins with robust efficiencies and short fragments suitable for Peptide synthesis are rare and have mostly been artificially created exhibiting poor to moderate coupling efficiencies only.

Scientists of the Westfaelische-Wilhems University Muenster and Sensient developed dopants for Organic Light Emitting Diodes (OLED). The tri and bi-dental platinum (II) complexes with phosphite or dianionic NNC/NNN ligands are triplet emitters with excellent quantum efficiencies.

OLEDs consist of electro-luminescent substances, embedded in a polymer matrix. To emit exzitones, an electric current, triggered energy transfer is needed. Useful electroluminescent dopants are metal complexes like platinum complexes. The quantum efficiencies depend on the electronic behavior of the ligands used.
Therefore useful and efficient substances like P-Phos are required.

Mutations in the lysosomal enzyme ß-glucosidase 1 (GBA1) cause Gaucher’s disease, the most common lysosomal lipid storage disease in humans. When GBA1 is absent or impaired, glycosylceramide (GlcCer) accumulates within the macrophage lysosomes, leading to liver and spleen enlargement, bone lesions and in the most severe cases, impairment of central
nervous system functions.

Production process of wood composites combining hot air and hot steam. This reduces the production time, production line and enables the use of any current binder.