Technology Offerings

Liquid biopsy based early breast cancer detection – SPAG6, NKX2-6, PER1 promoter methylation biomarker panel

Researchers of the University Medical Center of Aachen have developed a blood-based diagnostic test for breast cancer and its pre-cancerous stages, based on the grade and intensity of CpG promoter methylation of early breast cancer biomarkers, i.e. the genes SPAG6, NKX2-6 and PER1 (the “SNP panel”). Combined, these three genes provide an opportunity to easily test for breast cancer, starting from a patient’s blood sample (Liquid biopsy). It is very likely that a blood-based test would increase compliance of women to participate in medical prevention of breast cancer. In addition, this concept may allow to broaden prevention to elderly women (>70 years) who currently are not invited to mammography screening.
In April 2016, a blood-based early detection system for colon cancer (the Epi ProColon test by Epigenomics AG) has been approved by the FDA. The RWTH Aachen blood test could be applied in an analogous way for breast cancer detection. Both tests have similar sensitivity and specificity, which may qualify the herein presented test for approval as well. A key argument for the approval of the Epi proColon test by the FDA has been the likelhood of increased acceptance by the relevant population thus reinforcing screening participation.
On behalf of the University of Aachen (RWTH Aachen), PROvendis offers a patent license as well as a research collaboration with licensing option.

Sili-Kill – Antimicrobial SiO2 Nanoparticles

A special process to coat SiO2 nanoparticles around with biocidal quaternary ammonium silanes has been achieved, so that the biocidal moiety points always outwards. Subsequently, the nanoparticles can be deposited on one surface from a dispersion of a simple solvent (for example alcohol). The forming surface coating acts purely contact active antimicrobial. That means, when touching, no toxic substances go over the contacting body. The new SiO2 nanoparticles are suitable for the antimicrobial coating especially in sanitary and wet areas, for example, of silicone joints. However, all surfaces in principle can be coated with them.

Non-Volatile Magnetic Flip Flop and Shift Register

The invention relates to a spin torque magnetic flip flop and a shift register incorporating such, enabling high operation speed, non­ volatility and reducing die space consumption .

lntrinsic Non-Volatile Logic-in-Memory with STT-MRAM

The invention relates to an electronic circuit comprising a plurality of 1T/1MTJ cells arranged in array and being selectable by word lines (Wls) and bit lines (Bls), wherein each 1T/1MTJ cell comprises an
STT-operated magnetic tunnel junction (MTJ) and an access transistor.

3D-Printing using focused super sonic beams

The invention belongs to the field of generative/additive manufacturing (better known as „3D printing”). Additive manufacturing describes usually building up a structure layer by layer from a granulate or liquid using physical/chemical processes as melting or curing of a material.

New process for creating storage-stable, 12-month non-perishable „ESL-H-Milk“

In order to increase the storage stability and shelf life of milk, a new treatment process has been developed at Hohenheim University, one that also requires comparatively low treatment temperatures.
The milk can be kept at room temperature for up to a year and yet impresses with its good sensory properties and low vitamin loss.

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