Technology Offerings

The technology enables the fast and competitive production of specific ALA via biotechnological process technology. The production of aminolevulinic acid (ALA) is the first step in the biosynthesis of tetrapyrroles and porphyrines (like Chlorophyll, vitamin B12, heme). Recently ALA has attracted interest as a selective and biodegradable herbicide and insecticide. Besides ALA can be applied in the photodynamic therapy and treatment of various kinds of cancer.
Administration of ALA in the tumorous tissue leads to a porphyrin formation inside the cells. Accumulated porphyrins generate reactive oxygene species when excited by light which can lead to death of the tumorous cell. On behalf of the University of Bielefeld, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development.

By decoupling cell growth and productivity of biosynthesis the new method and associated Escherichia coli strain allow for an increase in productivity by a factor two to three.
This could not only be interesting for pharma industry, e.g. by increasing the capacity of insulation production, but for biotechnological synthesis of succinic acid as well. The demand for succinic acid as a component of plastics such as polyamides or polyesters is estimated to amount to 250,000 tons per year.

A new and cost saving method makes it possible to combine different components of any form. Manyfold material combinations such as carbon fiber composites and metals can be combined easily. With the material friendly technique high quality welding seams can be manufacured in a flexible manner without affecting the components global-thermally.

Scientists at the University Göttingen developed a monoclonal antibody against a biotinylable peptid (Epitope-Tag) called AP-tag or Avi Tag. This small peptide served as a substrate mimic for biotin ligase (BirA). Anti-AP antibodies are useful tools in the analysis of AP-tag fusion proteins.

A novel Fourier Transform Infrared (FTIR) spectroscopy based approach for rapid and reliable differentiation of fresh from frozen/thawed meat or fish. This fast and inexpensive high throughput technique represents a powerful tool to ascertain correct labeling of meat and fish.

Gerät zur Messung von mechanischen Eigenschaften von Böden und Oberflächen, dass ohne Führungselemente auskommt, keine Sensoren für Weg oder Geschwindigkeit benötigt und Energierückgewinnung, Federkonstante, Kraftreduktion und Resonanzfrequenz misst.