Technology Offerings

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that leads to progressive joint deformity, disability, and occasionally premature death. Emerging evidence suggests the utility of histone deacetylase inhibitors (HDACi) in the treatment of chronic immune and inflammatory disorders such as rheumatoid arthritis. Several studies have shown the decreasing effect of selective HDAC6 inhibitors on the secretion of pro-inflammatory cytokines in vitro and a significant therapeutic response has been demonstrated in animal inflammatory disease models.

Food industry is seeking for strategies to enhance production throughput in order to reduce costs. One bottleneck is not the production process itself, but the subsequent quality control analysis of each production charge. The herein described invention expedites this process and is therefore of interest for contract analytic labs as well as for food production companies with an own quality analysis laboratory. The culture medium has been optimized for osmo-tolerant yeast growth and has been tested and validated in comparison to conventional culture media. The invention is ready for industrial use.
On behalf of the University of Applied Sciences Ostwestfalen-Lippe, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development. In case of interest we will be pleased to inform you about the patent status.

The herein presented new architecture of a bioreactor basically consists of an inner and outer cylinder, whereas the disperse phases are added in either one of the cylinders. The two key elements of the design are baffles on the upper end of the inner cylinder, which prevent a mixture of the disperse phases, in combination with a collection device placed on top of the inner cylinder. This design allows continuous product extraction by means of biocompatible solvents and a simultaneous oxygen supply.
Moreover, the addition of both disperse phases and the regulation of the loop flow can be adapted continuously and anytime through steering of the volume flow rates. With this invention three or four phases can be brought together intensively with only small transport hindrances while the two additional disperse phases are spatially separated. On behalf of the University of Aachen (RWTH Aachen), PROvendis offers access to rights for commercial use as well as the opportunity for further co-development and evaluation. The design of the reactor and the requested fluid dynamics can be assisted by the inventors.

We present light-emitting electrochemical cells based on hybrid lead halide perovskite nanoparticles. The latter are not oxygen sensitive and therefore the LEECs can be produced from solution or by spraying. The resulting LEECs are characterized by a four layer structure. They feature moderate luminance (> 2 cd/m2) and efficacies (> 0.02 cd/A), but high stabilities even after keeping
the devices under ambient conditions.

A set of novel platinum (IV) oxaliplatin derivatives that are tumour-targeted through albumin binding have been synthesized and tested in vitro and in tumorigenic mice, with highly promising results.

The researchers led by Prof. Dr. med. dent. Sven Reich developed a scanning aid that replaces the conventional retaining-plate for the extra-oral scanning. The scanning aid now provides the intra-oral scanner a structure around the implant abutment. Thereby, the abutment can be extra-orally optically molded with an intra-oral scanner for the first time. The intra-oral data and the extra-orally gained records using the scanning aid are then fused together. For this end, the scientists have developed an own software.
The target of a much shorter course of treatment with a single session on the patient instead of two to four sessions is made possible by means of the scanning assistant, without the necessity of expensive laboratory scanners. This allows the much quicker method for both the doctor and the patient, and keeps a consistent quality with significant savings of financial resources.
A patent application has been filed at the European Patent Office. A functional prototype has been developed and tested with various available intra-oral scanners. The scanning assistant is the subject of further developments of the Department of Prosthodontics at the University Hospital of Aachen.
PROvendis offers on behalf of the University Hospital Aachen, licenses to the invention for interested companies.