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A new class of molecules with bifunctional properties can influence cortical neuron growth, with the potential for slowing or even reversing neuronal degeneration in Parkinson's patients.

The major clinical challenge in treating NPM-ALK+ anaplastic large cell
lymphomas (ALCL) is its high rate of relapse. Researchers of the Medical
University of Vienna identified high expression of PDGFRß in the NPMALK
induced ALCL. Pharmaceutical targeting of PDGFRB using a tyrosine
kinase inhibitor (TKI) strongly reduced tumor size in SCID-mice xenografted with NPM-ALK mouse tumor cells, and increased the survival of NPM-ALK+ transgenic mice by more than 90%. These data provide evidence for the use of FDA approved tyrosine kinase inhibitors for the effective treatment of lymphomas and encourage the development of specific clinical trials.

The invention describes a system, which is used to monitor the ingrown and loosening status of an implant.
To achieve this, body sound and ultrasound sensors are placed on the surface of the prosthetic. These sensors are able to detect micro friction processes, caused by a relative movement between the artificial hip and the surrounding soft and hard tissue. In addition, the system is capable of using ultrasound to monitor the ingrown and loosening status.
By doing so, the invention delivers a measurement system for a non invasive and radiation free examination of the loosening and the ingrown status of hip replacement implants. This system would be able to reduce the number of unnecessary revision surgeries and thus could be able to reduce the costs caused by such opera-tions.

The invention delivers a new constructive design of the ultrasonic transducers to enhance the usability of ultrasonic material testing. The device described in the invention is constructed with a great number of piezo electric transducers on the surface of the probe. Those piezo electric elements are placed like mosaics on a flexible surface, which is placed on a rodshaped carrier. This surface is now able to adapt to the surface of the testing body, which means that a great number of complex surfaces can be tested with this system.
The carrier includes several channels, which are able to constantly supply the ultrasonic transducers with a gel. This gel is used as the coupling agent for an opti-mized sound transfer.

A solution for the known difficulties is given with this invention. Therefore a rotating valve is described. This valve controls the fluid flow in the system without getting in touch with the fluid itself. To do so, the valve heads are pressed on the flexible fluid pipes, which causes the flow through this point to stop. The valve heads are moved by electrically con-trolled actuators which perform a rotation movement. Unlike with membrane valves, additional energy to keep the valve open or closed is not required. Furthermore it is possible to use miniature servo actuators for the movement of the valve heads.

The invention relates to a system, in which the flow in the channel is caused by a contact device, which is not in direct contact with the fluid. The flexible fluid channel is compressed by force which leads to closure of the channel. Now the contact device is moved along the chan-nel which causes an internal wave that transports the fluid. The pump itself emits force onto the channel without being a part of it. By doing so, it is possible to use the pump with one time use systems, because it is possible to remove the pump from the system without the need of disconnecting the pump from any channel attachments. Furthermore it is possible to reuse the pump system which helps to reduce costs. Furthermore it is possible to use this pump together with aggressive solutions, because the pump itself is not in any contact with the fluid.