Technology Offerings

Pathological calcification processes in the human body are often the
beginning of a series of diseases which relate to organ systems such as the vascular system of the heart, and kidney. As a consequence of metabolic diseases such as diabetes, calcification processes can lead to severe impairments of health or to death. Therefore, it is of scientific and economical interest, to develop new approaches for quick and inexpensive treatments of these diseases. Already known calcification biomarkers provide an indication of occurring calcification processes but still can’t make a statement about triggering factors, which will be possible with our in vitro calcification model, CALCI-QUICK.

Researchers of the Medical University of Vienna have identified highly
active synthetic chalcones derived from the chalcone scaffold. These
cytotoxic compounds were found and developed by modifying the
chalcone lead structure concurrent with in vitro tests to evaluate their
cytotoxic potential in different cancer cell lines. Compounds were
thoroughly tested regarding their efficacy in inhibiting proliferation and
viability in cancer cell lines of the hematopoietic system. The combination of the new chalcone compound with the targeting agents, Idelalisib and Ibrutinib, which are novel compounds in the treatment of hematological malignancies, displayed higher cytotoxicity on CLL cells than Idelalisib and Ibrutinib alone.

The proposed methodology is an important step towards image-analysis
based individualization of patient management and treatment in one of the most cost-intensive fields of modern medicine. We propose to
identify and quantify retinal morphology using deep learning algorithms
such as convolutional neural networks (CNN) and to predict future
disease progression patterns and treatment response in patients based on spatio-temporal signatures.

At University of Bremen a new wound healing strategy has been presented: The team of the Wound Repair Unit at the Centre for Biomolecular Interactions Bremen (CBIB) has shown the influence of lung surfactant on keratinocytes and the benefit of these interactions for cell migration and wound resurfacing. Lung surfactants contain phospholipids and surfactant proteins and are used as standard therapy for respiratory distress syndrome in preterm infants.

There is currently a strongly growing need for methods and chemicals for the preparation of large biological samples for three-dimensional imaging. The invented substance and protocol are of high interest for any supplier or company in the field of microscopy and imaging techniques. The unique selling proposition is that the herewith offered invention constitutes the sole methodology optical clearing of biological samples without use of harmful chemicals combined with high quality fluorescence preservation. The invented substance and protocol is routinely used by the inventors and has thus been shown to be robust for general laboratory usage.
On behalf of the University of Duisburg and Essen, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development, e.g. of a kit. In case of interest we will be pleased to inform you about the patent status.

The present invention relates to a plant and a procedure for separating gold or other metal particles from a mixture of particles by applying dielectrophoresis. The physical separation method specifically separates metals, e.g. gold, from a suspension. This is accomplished by a special configuration of electrodes allowing for the creation of an electric field which is selective to metallic particles. The new method replaces environmentally hazardous cyanide leaching almost completely and thus considerably reduces the amounts of the chemicals that need to be applied.