Technology Offerings

Inhibitors of Adipose Triglyceride Lipase (ATGL) for the treatment of Diabetes II and tumour-induced cachexia

The University offers a new technology addressing at least the two markets of tumour-induced cachexia and diabetes type II. Cancer has become a constantly increasing problem and thus about 1 % of all people in highly developed countries are hit by cachexia, leading to approximately 9 million patients for Europe, Japan and the US. Furthermore, diabetes type II is one of the major lifestyle diseases in the modern world.

New Enzymes for production of aldehydes – Enzymatic alkene cleavage

The University offers an unprecedented enzyme that cleaves alkenes to the corresponding aldehydes at the expense of molecular oxygen. This mild and selective oxidation method has broad applicability either for the preparation of aldehyde intermediated or for the chemical production of aromatic essences and flavourings enabling a reduction of chemical solvents and cheaper production processes. The markets for using this enzyme are the fine chemicals and the aromatic/flavourings industries.

Non-destructive energy determination of ion beams

Ion beams are applied in many fields, such as medicine, semiconductor industry and basic research.
The invention intoduced here relates to a measurement device and a method to determine the energy of accelerated ions without destructing them.

Overlap Fix – High performance textile structures for composites through open reed weaving

Inventors of the RWTH Aachen University filed a patent relating the production of the multiaxial enforcement fabrics for textile composites with ORW (Open Reed Weave). To avoid load path interruptions in composites with textile enforcement, an overlapping of two yarn systems in the textile, by means of a special weaving pattern, leads to continuous load path in bias direction, reaching a “Triaxial” fabric, which is the main approach of the investigation. The Angle of additional reinforcement direction is adjustable and the calculated necessary overlapping is 16.28 mm length.
The system´s capability was verified by conducting three-point bending tests. These are performed varying the overlapping length, testing carbon and glass fibers and using reference samples as follows: [0/90°] fabrics and [0/90/45°] fabrics with continuous reinforcement. The results were successful in all cases. PROvendis offers licenses for interested enterprises on behalf of the University of Aachen.

Functional surface modification inspired by the mussel adhesive protein – the most stable adhesive in nature

Permanent and stable surface coatings are suitable to be achieved on medically relevant metals (e.g. titanium) and glass via trimeric catechol derivatives. Furthermore, various active agent molecules such as PEG, antibiotics, enzymes and other biomolecules may be coupled to natural molecules by means of simple chemical reactions (?click reactions?). The new tripodal ligands offer considerable advantages in comparison to the state of the art monovalent metal binders currently used.

Humanized anti-CCR2 Antibody for the Therapy of MS and RA

Scientists of the University of Göttingen and of the University of Regensburg developed in collaboration a proprietary anti-CCR2 antibodies for the therapy of Multiple Sclerosis (MS) and potentially Rheumatoid Arthritis (RA).The lead candidate Doc-2 has been humanized in collaboration with the MRC Technologies. It targets the CCR2 receptor and modulates the autoimmune process through depletion of CCR2+ monocytes.

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