Technology Offerings

A new and convenient synthesis method has been developed for coupling a ligand (e.g. PEG, peptides) through a cleavable disulfide linkage to an oligonucleotide at the 2´ position of a ribose ring. The resulting oligonucleotide conjugates are taken up efficiently into cells without the need for a transfection agent, and the 2´ OH group modification has
a positive impact on stability, allowing natural (phosphodiester) oligonucleotide sequences to be used. Preliminary in vitro experiments have demonstrated effective target gene down-regulation.

Novel synthetic lignans to affect inflammatory processes related to surgical cardiovascular intervention have been identified. The compounds may have highly beneficial effects for preparation of cardiac by-pass implants as well as for stent conduits.

Researchers of TUW and MUW have found that cardiomyocyte-like cells may be obtained not only from omnipotent or pluripotent mammalian cells,
but also from lineage committed cells, such as skeletal myoblasts when cultured in the presence of substituted pyridine- and pyrimidine-compounds.

The invention intends to provide coumarin based nickel-dithiolene complexes, to selectively detect mercury (II) ions in the organism. Based on a Ditholen-ligand, molecules have been developed which can be used to determine the presence of heavy metal ions. Design, manufacture and the properties of a system based on a coumarin nickel dithiolene complex are described, which operates in the wavelength range of ~960 nm with high selectivity and sensitivity for mercury ions even in the presence of other metal ions (eg. Ag+, Al3+, Ca2+, Cu2+, Mg2+, Na+, Sn2+) that can be used in a simple UV / VIS spectroscopy.

The novelty of the present invention is to prevent the disturbance of encryption systems and thus lead to better data se-curity. In addition it is aimed at users who have little or no background knowledge. The inventive approach to security is based on the combination of an LCD display and the encryption method “One Time Pad”. This results in the advantage that on the user side, the compromised device (PC, smartphone, etc.) only sees the encrypted information itself. At this time the decryption takes place at a sec-ondary LCD display, which is separated with the decoding key from the actual device. Thus, none of the decoded mes-sage transmission takes place on an in-fected device (by spyware or malware), enabling secure transfer of information in spite of monitored devices and commu-nication channels.

The present invention relates to an antibody that exhibit a high affinity and mono-specificity for the A1/B-domains of human CEACAM1. Thus, it is suitable to detect the membrane anchored, the cleaved soluble CEACAM1 and most of its derivatives. It is of use in several research applications, including ELISA, WB, IP, IHC, fluorescence microscopy and flow cytometry. In addition, the monoclonal antibody (mAB) is suitable for use as a diagnostic tool for the detection of inflammatory disorders (e.g. sepsis, multiple sclerosis) as well as for solid tumors, and applies for therapy monitoring of the latter.
Cancer patient data have been generated that support the diagnostic potential. A German patent application has been filed. On behalf of the University of Duisburg-Essen, PROvendis offers access to the antibody for commercial use.