Technology Offerings

The new technology provides a simple and inexpensive process for the synthesis of proteins that exhibit reliable functionality by posttranslational modifications, like e.g. glycosylation. Furthermore, the assembly of protein complexes is enabled. These are secreted from the cells into the medium and can be therefore easily obtained.

Novel peptidomimetic furin inhibitors strongly inhibit the furin-dependent activation of several viral surface proteins and bacte-rial toxins. Therefore, these inhibitors are a promising new approach for the treatment of diseases, which are caused by furin-dependent infectious agents.
Such diseases are for example influenza, measles, mumps, yellow fever, canine distemper, anthrax, and diphtheria.

The new chimeric nucleases exhibit an increased preference and specificity for DNA cleavage sites composed of two or three recognition sites and allow single cuts in the genome which reduces the toxic side effects substantially.
The high specificity and preference of the new chimeric nucleases is based on a fusion of TALE proteins as DNA binding modules with a highly specific restriction endonuclease, PvuII, as DNA cleavage module.

A major challenge of construction within existing contexts is that renovated as well as newly built supporting structures have to comply with similar requirements regarding statics and outer appearance. E.g. component connections have to comply with standards in the fields of fire protection, corrosion protection and protection of historical monuments. Steel elements pasted into wood provide a solution for these rquirements.

GNSS enables the determination of positions by the help of a carrier phase with an accuracy down to some centimeters. The GNSS receivers typically determine the carrier phase by help of a phase locked loop continuously. However, up to now GNSS receivers are tracking the carrier phase of each satellite and each frequency separately. This is a big drawback since the strong spectral and spatial correlation between carrier phases is not being exploited which makes phase tracking error-prone. Furthermore, this leads to a number of phase jumps especially with low-cost GNSS receivers. The new patented invention comprises a vector phase tracking method, which processes the carrier phases of all visible satellites on all available frequencies simultaneously, thus using the spectral and spatial correlation of the measurement. It enables a continuous, smooth tracking of carrier phases, even when the signal strength (C/NO) of individual satellites breaks down by 20 dB. Therefore the method is very suitable for the use of low-cost GNSS receivers/antennas in environments with multiple faults and ionospheric scintillations.

Device for machining with rotatory ultrasound-vibrations: Reduced tool wear, very fine surface roughness and only little feathering of workpieces prove the advantages of hybrid manufacturing processes such as ultrasound machining. A newly developed device for machining combined with rotatory ultrasound oscillations enables a low-wear and thus more efficient processing of high performance materials such as hard metal, ceramic and fiber-reinforced plastics, compared to conventional methods.