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GNSS enables the determination of positions by the help of a carrier phase with an accuracy down to some centimeters. The GNSS receivers typically determine the carrier phase by help of a phase locked loop continuously. However, up to now GNSS receivers are tracking the carrier phase of each satellite and each frequency separately. This is a big drawback since the strong spectral and spatial correlation between carrier phases is not being exploited which makes phase tracking error-prone. Furthermore, this leads to a number of phase jumps especially with low-cost GNSS receivers. The new patented invention comprises a vector phase tracking method, which processes the carrier phases of all visible satellites on all available frequencies simultaneously, thus using the spectral and spatial correlation of the measurement. It enables a continuous, smooth tracking of carrier phases, even when the signal strength (C/NO) of individual satellites breaks down by 20 dB. Therefore the method is very suitable for the use of low-cost GNSS receivers/antennas in environments with multiple faults and ionospheric scintillations.

Device for machining with rotatory ultrasound-vibrations: Reduced tool wear, very fine surface roughness and only little feathering of workpieces prove the advantages of hybrid manufacturing processes such as ultrasound machining. A newly developed device for machining combined with rotatory ultrasound oscillations enables a low-wear and thus more efficient processing of high performance materials such as hard metal, ceramic and fiber-reinforced plastics, compared to conventional methods.

Method for production of a mechanical stable and flexible polymer based ion conducting solid state polymer electrolyte membrane for the use in lithium based accumulators.

The invention describes a combined electricity generation and storage system, preferably based on renewable burnable gases e.g. from biogas plants or biomass gasification.

Spinal muscular atrophy (SMA) is an autosomal recessive disorder based on the loss of the survival motor neuron 1 (SMN1) genes. The severity of the disease is inversely correlated with the copy number of the main disease modifying gene SMN2.
In rare cases, siblings of SMA patients do not show SMA, although they carry exactly the same SMN1 and SMN2 gene status as their SMA affected relatives. So other genetic factors are able to fully protect homozygously SMN1-deleted individuals from developing SMA. The inventors found that this phenomenon might be caused by the overexpression of plastin 3, an actin-bundling protein, and/or low expression levels of the calcium sensing protein neurocalcin delta (NCALD). In vitro and in vivo studies show that inhibitors of neurocalcin delta (NCALD) are suitable for treating and preventing such disorders in a patient. Said inhibitors are, likewise, effective tools for in vitro neuronal differentiation and maturation, and restoration of impaired endocytosis.

Light-sheet-based fluorescence microscopy (LSFM) is a powerful method to analyze 3D living or fixed biological samples – such as cell cultures, embryos, or tissue – with high temporal resolution. The novel sampling device facilitates high-throughput LSFM measurements without loss of imaging quality.