Technology Offerings

Light-sheet-based fluorescence microscopy (LSFM) is a powerful method to analyze 3D living or fixed biological samples – such as cell cultures, embryos, or tissue – with high temporal resolution. An advanced method has been developed to minimize negative effects due to bleaching and light-induced stress. Additionally, it is suited for larger sample sizes.

In orthodontics, there is a multitude of intraoral devices and wires that can be activated by bending. However, due to restricted access, wire bending is often difficult if not impossible, especially in the palatine region and lingual of the mandible. Moreover, in many cases mirror-inverted pliers would be necessary for respective bending on the other side of the oral cavity. So far, there are no orthodontic pliers available, that enable ergonomic wire bending on both sides of the oral cavity. The present invention solves this problem by connecting the two handles with an olong hole system. According to the invention, the one-prong branch can be swiveled to the other side of the two-prong branch, thus allowing mirror-inverted application. A locking mechanism is activated when the pliers are closed to prevent accidental shifting of the branches. Another aspect of the invention is an convenient working angle between branches and handle, which facilitates intraoral application. A design model is available for demonstration.

The technology describes novel ionic liquids. With this technology a directed choice of substituents, attached groups and the anion is possible which makes it possible to create ionic liquids with special properties for different applications.

The method allows very consistent classification of tumor entities (especially brain tumor sub-types) by analyzing the methylation pattern of genome wide CpG positions.

Biotinylated molecules, like proteins or peptides, DNA, RNA and PNA are quantitatively released from streptavidin complexes by adding a mixture of SX. After elution and removal of SX, e.g. by evaporation, the biotinylated molecules can be used for subsequent applications and analyses.

The mouse model faithfully mimics clinical conditions in HCC and allows evaluation of novel therapeutic strategies like immunotherapy or antiangiogenic therapy or vaccination. The tumor induction is tightly controlled by cre/loxP-system in a dose-dependent manner.