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Moguntinones, a class of small molecule compounds comprise 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives with tumor and vascular targeting properties. The present invention relates to the use of Moguntinones for treatment of colorectal or gastric adenocarcinoma.

Tumor growth and metastasis are highly associated with the overexpression of protein kinases. Therefore protein kinases are an interesting class of target molecules for improved therapeutic attempts. These proteins are known to regulate the majority of cellular pathways including such relevant for control cell growth, movement and death – all processes relevant for cancer growth and progression.

A physiological process focused on in development of anti-cancer agents is apoptosis, a controlled form of cell death eliminating damaged, aberrant, infected, old or superfluous cells. In particular often mucosa tissue such as gastrointestinal mucosa is characterized by a rapid epithelial cell turnover in which homeostasis is maintained predominantly by apoptosis.

One essential prerequisite for growth and metastasis of cancers which form tumors is angiogenesis, a process involving the formation of new blood vessels from pre-existing capillary endothelial cells. Tumor cells may enhance angiogenesis by overexpression of proangiogenic factors, e.g. VEGF or interleukins. In general, this is especially pronounced with tumors having a high microvessel density as well as a particular aggressive behavior and high tendency to metastasize. Therefore, inhibitors of angiogenesis are researched as antitumor agents.

[Ref. UMZ252]

The inventive method allows the context-sensitive indexing of hemodynamic parameters. For the indexation of hemodynamic and biochemical parameters a more specific adjustment based also on non-biometric data can be used to more accurately assess and easily access the parameters and thus simplify and improve the care of critically ill patients.

The present invention addresses the AD-converter in the receiver which is in respect to power consumption a highly crucial component. By reducing the resolution down to 1 bit and simultaneously improving the signal-to-noise ratio by a new demodulator concept the invention offers a cost and power efficient design for the RF front-end.

Eye drops of blood serum are an established and very effective therapeutic agent in many ophthalmological diseases such as keratitis and dry eye syndrome.The production of serum eye drops and the partition in one-day-doses must be operated under clean room conditions in order to prevent any contamination of the eye drops.
This product allows a fast and easy production of eye drops from blood serum without the need of a clean room laboratory. The single use product utilizes a closed system, which guaran-tees the sterility of the serum eye drops.

Electrical sensing array for the detection of multiple biological or chemical species in complex samples with applications e.g. in chemical analysis and medical diagnostics.
Such a device allows for simultaneous and spatiotemporal detection of concentration gradients in test samples. A direct integration of the proposed sensor array into many kinds of sensing platforms like microfluidics or lab-on-a-chip systems is possible and a combination with conventional optical read-out techniques can be realized.

Itaconic acid (ITA) – also known as methylenesuccinic acid or butanedioic acid – is one of the top 12 bio-based chemical building blocks and thus a promising platform compound for production of biofuels, chemical compounds, including e.g. detergents, and polymers, including plastics and artificial glass.
Itaconic acid (C5H6O4) is an organic dicarbonic acid which is soluble in water, ethanol, and acetone.
The new method for production of itaconic acid uses genes encoding for the itaconic acid biosynthesis pathway of the genus Ustilago maydis.