Technology Offerings

Rocaglamide makes tumour cells more susceptible to anti-proliferative agents while leaving normal cells unaffected. This allows dose reduction of apoptosis inducers and in parallel improves dramatically the patient’s condition during cancer treatment.

The invention provides a needle-based navigation system for CT-guided radiofrequency ablation of the liver. The key facts are: (1) Precise intervention and navigation aid for soft tissue surgery; (2) Real-time observation and supervision; (3) Inexpensive hardware/software equipment

Radiotherapy is a well-established method to treat certain tumor types in particular brain tumors. For fixation of the patient's head a “mask” is used, with is connected to the plate where the patient is located on. The novel technology describes a non-invasive procedure, where the patient mask is produced by rapid prototyping based on CT/MR data.

Specific inhibition of histone deacetylases by BMP4 efficiently restores aberrant signaling pathways and biological features in experimental neuroblastoma at nanomolar concentration without unfavorably targeting untransformed cells. In addition, recombinant manufactured BMP4 is already established for other indications (osteoporosis and type 2 diabetes), which should support the approval for this new indication.

The peptides identified by our inventors block the intracellular activity of the HPV16 E6 protein and thus increase sensitivity of tumor cells towards apoptosis. This effect is highly specific for HPV16-containing tumor cells.

Method for the enrichment of diagnostic target molecules based on CD24 positive exosome purification, enabling the development of mainly cancer or fetal diagnostics and reducing false negative test results due to diluted diagnostic target molecules.