Technology Offerings

The present technology provides 3'-photolabile nucleoside derivatives for producing nucleotides. The resulting oligonucleotides built up on the support by light-controlled synthesis are linked to the solid phase via the 5' end and thus can be used for investigating reactions that require free 3'-OH ends, for example certain DNA-enzyme interactions.

OPoLiCom is a system that continuously monitors the access impedance over frequency. If the access impedance spectral density below a threshold value, in the respective frequency range, no power is fed. Since the maximum power consumption of a PLC transmitter is limited, it ensures that in the frequency ranges with sufficiently high access impedance sufficient power can be fed. This is necessary for a good signal-to-noise ratio. By using OFDM with strong channel coding as in the just now standardized method, the absence of a portion of transmission frequencies can be compensated without any information to the receiver. This allows a standard-compliant implementation.

The invention at hand provides novel inhibitors for human proprotein convertase, which have antibacterial and antiviral effects. These inhibitors are multibasic, N-terminally modified tetrapeptide derivatives having a C-terminal P1-arginine mimetic. In contrast to previous active substances against bacterial and viral diseases, the substances presented here do not apply to the pathogenic organism, but the host, so that there is no development of resistance to contend with.

The invention describes a method for the in-situ conversion of chemically fixed carbon dioxide into low-molecular weight organic compounds by direct heterogeneous catalytic or electrochemical hydrogenation.

Scientist at the University of Stuttgart, Germany, have developed a new microtip measuring catheter that is equipped with a triaxial acceleration sensor and several pressure sensors around its circumference. The novel urodynamic catheter has been specifically developed for the diagnosis of urinary incontinence. Its considerable improvement in diagnosis allows for an optimized treatment of incontinence. A prototype of the catheter is currently subject to animal testing.

he novel radiolabeled exendin derivatives provide a highly specific diagnostic tool for the detection of beta cells in the pancreas of patients at risk of developing diabetes or already having diabetes. An imaging protocol has been developed that allows single time point quantitative SPECT/CT imaging to allow for simple, time-efficient clinical imaging.
The product is ready-to-use for clinical applications and gives for the first time the opportunity for detection of changes in beta cell mass in persons with diabetes or at risk to develop the disease. The possibility of beta cell mass quantification is fur-thermore associated to the chance of validation of therapy success with already available medicaments or new drug candidates that may preserve or increase beta cell mass.