Technology Offerings

Optical fluorescence and gamma-labeled radio-pharmaceutical imaging offer complementary ways of probing and assessing the physiology of small animals. With the increasing use of both methods for functional molecular imaging in small animal models for applications such as cancer research and drug development, it has become more important to integrate their results, particularly for studies of the same animal. This can be performed through image registration of separate studies or through simultaneous tomographic acquisition with implicit registration of the two imaging modalities. DKFZ developed an optical imaging detector for fluorescence and bioluminescence in small animal imaging, which is compatible for single-photon emission computed tomography (SPECT).

New method for producing a highly diverse antibody library, where pro-teins/antibodies can be selected for specific applications. A large and, compared from cell to cell, highly uniform number of antibodies is covalently attached to the surface of a eukaryotic cell. Using this technology, specific antibodies can be selected together with the presenting cell out of a high number of cells in a comparatively easy way. The technology can also be used humanizing a hybridoma cell line by enabling the homologous recombination of the constant do-mains of human immunoglobulins with the respective gene.

The present technology provides 3'-photolabile nucleoside derivatives for producing nucleotides. The resulting oligonucleotides built up on the support by light-controlled synthesis are linked to the solid phase via the 5' end and thus can be used for investigating reactions that require free 3'-OH ends, for example certain DNA-enzyme interactions.

OPoLiCom is a system that continuously monitors the access impedance over frequency. If the access impedance spectral density below a threshold value, in the respective frequency range, no power is fed. Since the maximum power consumption of a PLC transmitter is limited, it ensures that in the frequency ranges with sufficiently high access impedance sufficient power can be fed. This is necessary for a good signal-to-noise ratio. By using OFDM with strong channel coding as in the just now standardized method, the absence of a portion of transmission frequencies can be compensated without any information to the receiver. This allows a standard-compliant implementation.

The invention at hand provides novel inhibitors for human proprotein convertase, which have antibacterial and antiviral effects. These inhibitors are multibasic, N-terminally modified tetrapeptide derivatives having a C-terminal P1-arginine mimetic. In contrast to previous active substances against bacterial and viral diseases, the substances presented here do not apply to the pathogenic organism, but the host, so that there is no development of resistance to contend with.

The invention describes a method for the in-situ conversion of chemically fixed carbon dioxide into low-molecular weight organic compounds by direct heterogeneous catalytic or electrochemical hydrogenation.