Technology Offerings

Lasers as sources for coherent and intense light are used in many high-tech applications and medical devices. Generally, the generation of Laser-light is characterized by a significant level of optical and electrical energy input and low efficiency.
Contrary to the Laser, BEL utilizes an organic dye/polymer system, which is arranged between two mirrors forming an optical micro-cavity. The incoming light is multiply reflected between the mirrors, giving rise to an effective photon mass and a confining potential – key prerequisites for the Bose-Einstein condensation of photons. Thermalisation is achieved by the photon scattering off the dye molecules, resulting in a strong light concentration effect into the centre of the confining potential, where the potential energy is minimized. The spatial concentration is a consequence of the thermalisation of the trapped photon gas.

Commercial Opportunity:
For many Laser applications, coherent but not necessarily monochromatic light is required. The strong light concentration effect of BEL and the generation of coherent light with high intensity offer opportunities for a range of applications. For these applications, BEL can be a efficient light source for coherent visible and UV light. In contrast to a Laser, where significant share of the energy is lost in heat, BEL allows the design of an efficient solid state “cold Laser”.

T-cells play key roles in many diseases: they defeat infections, attack “self” tissue in autoimmune diseases and they attack tumor tissues. T-cell antigens are in direct causal relation to pathogenesis.

Antigen determination of tissue–invasive lymphocytes: The invention is a method for the identification of T-cell epitopes of 7-10 amino acids in length (e.g. linear antigen sequence). No prior information about the nature of the antigen entity required. It is an HTS method with extremely high sensitivity (one positive cell detected in 10,000,000 negative cells within a few hours).

The present invention HerpHu-mAb provides a humanized anti-HSV antibody that is capable of neutralising HSV infections and inhibiting the cell-to-cell spread that is crucial during HSV reactivations.
HerpHu-mAb revealed as highly effective in prevention of ocular HSV infections as well as lethal infections under immune-suppressed conditions in the corresponding animal models. Moreover, HerpHu-mAb proved to be capable of overcoming drug resistant HSV infections. Since HerpHu-mAb specifically binds to a highly conserved surface antigen that is essential for the viral fitness, the development of drug resistance is most unlikely.
Due to the high infection rates of the population and due to the frequent reactivation of the lifelong persisting virus, HSV is of particular clinical relevance. A passive immunoprophylaxis is currently not available. A couple of experimental vaccines for active immunization against HSV1 and HSV2 showed no verifiable success.
HerpHu-mAb represents a new alternative for the treatment and prevention of HSV infections that is capable of overcoming drug resistances to conventional therapies.

Ionenstrahlen finden in vielen Gebieten wie Medizin, Halbleiterindustrie und auch in der Grundlagenforschung Anwendung. Hierbei werden hohe Anforderungen an die Qualität des Ionenstrahls gestellt, so dass die Bestimmung der Energie des Ionenstrahls, d.h. seine Kalibrierung, essentiell ist.
Die vorliegende Innovation beschreibt ein Messgerät und ein Verfahren um die Energie beschleunigter Ionen zu bestimmen ohne diese zu stören.

Scientists at the University of Hohenheim, Germany, have developed the first biological and bee-friendly Varroose control method. The method exploits the fact, that female mites exude a pheromone which incites the mating behavior of the males.
After isolating the pheromone and identifying its components, followed another breakthrough with the discovery, that single components of the pheromone affect the mating behavior effectively, too. Currently the scientists run successful field tests using oleic acid, a low-priced component, which is unproblematic with regard to food regulations and suitable for application as a spray.

The hierarchical and precisely controlled process creating ribosomes in living cells is known as ribosome assembly and is relatively little researched. In the eyes of many experts the early processes in the creation of ribosomes offer attractive targets for antimicrobial agents. The systematic search for such substances is made more difficult by the fact, that currently no suitable screening processes exist.

The present invention consists of stable bacterial strains with ribosomal subunits incorporating fluorescent markers, which have growth characteristics similar to wild type, and which have an intact translation apparatus. The positioning of the fluorophores allows for disturbances in the ribosome assembly to be detected in vivo by a fluorescence-based readout process. The process has been optimized for use with multi-well plates and thus is suitable for use in high throughput screenings (HTS).