Technology Offerings

Scientist at the University of Stuttgart, Germany, have developed a new microtip measuring catheter that is equipped with a triaxial acceleration sensor and several pressure sensors around its circumference. The novel urodynamic catheter has been specifically developed for the diagnosis of urinary incontinence. Its considerable improvement in diagnosis allows for an optimized treatment of incontinence. A prototype of the catheter is currently subject to animal testing.

he novel radiolabeled exendin derivatives provide a highly specific diagnostic tool for the detection of beta cells in the pancreas of patients at risk of developing diabetes or already having diabetes. An imaging protocol has been developed that allows single time point quantitative SPECT/CT imaging to allow for simple, time-efficient clinical imaging.
The product is ready-to-use for clinical applications and gives for the first time the opportunity for detection of changes in beta cell mass in persons with diabetes or at risk to develop the disease. The possibility of beta cell mass quantification is fur-thermore associated to the chance of validation of therapy success with already available medicaments or new drug candidates that may preserve or increase beta cell mass.

Lasers as sources for coherent and intense light are used in many high-tech applications and medical devices. Generally, the generation of Laser-light is characterized by a significant level of optical and electrical energy input and low efficiency.
Contrary to the Laser, BEL utilizes an organic dye/polymer system, which is arranged between two mirrors forming an optical micro-cavity. The incoming light is multiply reflected between the mirrors, giving rise to an effective photon mass and a confining potential – key prerequisites for the Bose-Einstein condensation of photons. Thermalisation is achieved by the photon scattering off the dye molecules, resulting in a strong light concentration effect into the centre of the confining potential, where the potential energy is minimized. The spatial concentration is a consequence of the thermalisation of the trapped photon gas.

Commercial Opportunity:
For many Laser applications, coherent but not necessarily monochromatic light is required. The strong light concentration effect of BEL and the generation of coherent light with high intensity offer opportunities for a range of applications. For these applications, BEL can be a efficient light source for coherent visible and UV light. In contrast to a Laser, where significant share of the energy is lost in heat, BEL allows the design of an efficient solid state “cold Laser”.

T-cells play key roles in many diseases: they defeat infections, attack “self” tissue in autoimmune diseases and they attack tumor tissues. T-cell antigens are in direct causal relation to pathogenesis.

Antigen determination of tissue–invasive lymphocytes: The invention is a method for the identification of T-cell epitopes of 7-10 amino acids in length (e.g. linear antigen sequence). No prior information about the nature of the antigen entity required. It is an HTS method with extremely high sensitivity (one positive cell detected in 10,000,000 negative cells within a few hours).

The present invention HerpHu-mAb provides a humanized anti-HSV antibody that is capable of neutralising HSV infections and inhibiting the cell-to-cell spread that is crucial during HSV reactivations.
HerpHu-mAb revealed as highly effective in prevention of ocular HSV infections as well as lethal infections under immune-suppressed conditions in the corresponding animal models. Moreover, HerpHu-mAb proved to be capable of overcoming drug resistant HSV infections. Since HerpHu-mAb specifically binds to a highly conserved surface antigen that is essential for the viral fitness, the development of drug resistance is most unlikely.
Due to the high infection rates of the population and due to the frequent reactivation of the lifelong persisting virus, HSV is of particular clinical relevance. A passive immunoprophylaxis is currently not available. A couple of experimental vaccines for active immunization against HSV1 and HSV2 showed no verifiable success.
HerpHu-mAb represents a new alternative for the treatment and prevention of HSV infections that is capable of overcoming drug resistances to conventional therapies.

Ionenstrahlen finden in vielen Gebieten wie Medizin, Halbleiterindustrie und auch in der Grundlagenforschung Anwendung. Hierbei werden hohe Anforderungen an die Qualität des Ionenstrahls gestellt, so dass die Bestimmung der Energie des Ionenstrahls, d.h. seine Kalibrierung, essentiell ist.
Die vorliegende Innovation beschreibt ein Messgerät und ein Verfahren um die Energie beschleunigter Ionen zu bestimmen ohne diese zu stören.