Technology Offerings

Fluorescence-based Monitoring of the Ribosomal Activity to Optimize Yield from Recombinant Proteins

In vitro transcription/translation systems (ivtt) are used in biotechnology mainly to produce recombinant proteins whose production in vivo would be toxic. The experimental analysis normally involves autoradiography, i.e. it requires the labelling of translation products with radioactive isotopes. Handling these isotopes is expensive, a potential health hazard and limits throughput.

The present invention consists of stable bacterial strains with ribosomal subunits incorporating fluorescent markers, which have growth characteristics similar to wild type and which have an intact translation apparatus. This opens the opportunity for measuring the translation activity in real time using fluorescence. It is possible to carry out experiments in a shorter time and at less cost in multi-well plates, varying several reaction parameters in parallel to optimize yield.

Feldgeführter planarer Präzisionsantrieb mit einem luftgeführten Läufer

Ein feldgeführter planarer Präzisionsmotor mit luftgelagertem Läufer ist
mit verkürzten planaren Antriebsspulen ausgestattet, die zwecks
energieminimierter Erweiterung des Verfahrbereiches in ihren X- und Y-
Koordinaten jeweils präzisionslineargeführt und bewegt werden und der
Bewegung des Hauptläufers synchron folgen.

High-density fibreboard made of renewable raw materials, suitable for free-form modelling

Scientists from Stuttgart University developed a flexible high-density fibreboard with slip-resistant and shock-absorbent properties. The fibreboard consists of 80 % to 90 % straw, a natural, annually renewable fibre and agricultural by-product. It can be produced free of formaldehyde and isocycanate, making it the ideal solution for various indoor applications and minimizing the health risks during the product's entire life cycle. In addition to being recyclable and compostable the new fibreboard is highly flexible and therefore suitable for designing free-form furniture and interior spaces.

Efficient high-performance PCI-Express network

We present a novel network design for high-performance computing (HPC). Our network architecture provides a scalable, low-cost, and power-efficient network with very high bandwidth and low latency.

Hybrid Fluorescent Nanoparticles with Outstandingly High Light Intensity

Researchers at the Karlsruhe Institute of Technology (KIT) have successfully developed low-cost, fluorescent dyes with especially high light intensities. These inorganic–organic hybrid dyes can be synthesized easily and isolated, stored and redispersed in common solvents (ethanol/water). They can be excited using blue light (UV or blue light from LED) and emit depending on their composition in the blue, green, red or infrared spectrum. Preferred are applications in the field of medical diagnostic and therapeutic, advertising material and safety equipment (fluorescent marker).

Alzheimer Disease: New Target Structure for the Development of Pharmaceuticals

At present about 18 million people worldwide suffer from Alzheimer disease, a neurodegenerative disorder which leads to dementia. The pharmaceuticals currently registered for the treatment of Alzheimer are only able to reduce symptoms marginally and delay progression of Alzheimer disease to a limited extent. The novel preventive target structure, the APP-AICD/ Fe65-PTB2 complex, offers a new chance for the development of a possible pharmaceutical for a causal treatment of Alzheimer disease.

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