Novel electro-spun fibers with integrated molecular switches (e.g. spin-crossover compounds) offer a multitude of interesting applications in the field of bio-medical research and microsensor technology. Future applications can be the new implants like e.g. cochlea implants.
Chinese Hamster ovary (CHO) cells are commonly used as a mammalian expression system for the production of recombinant proteins. They are one of the few cell types that can be grown at high cell density as the cells are resistant to metabolic stress. However, given the considerable production costs it is of major importance to maximize the recombinant protein yield. The present invention allows for significantly increasing the recombinant protein expression level in CHO cells using a standard promoter. This is achieved by silencing the Galectin-1 gene through RNAi. The lentiviral Galectin-1-knockdown (>90%) increases the expression level of the protein of interest more than 1,5-fold. No further amendments are required.
The invention concerns a process for the production of bifurcated vascular prostheses by the polymer-processing technology electrospinning.
The present innovation provides stable aqueous suspensions of water-insoluble, but biodegradable diblock copolyesters which can be further processed in multiple ways, for instance via electrospinning.
The novel fuel cell electrode has a porous and mechanically stable layer due to its production via selective laser melting and therefore comprises a high power density at a low power-to-weight ratio and can be used at a wide range of temperatures.
Scientists at Aalen University have developed a device which allows the rotation of samples. It can be used in conjunction with a range of microscopy methods, including single-plane illumination microscopy (SPIM) and laser scanning microscopy. This enables scientists for the first time to observe 3D samples from all sides using conventional microscopes. Since the sample is kept in a fixed position relative to the microscope, the method opens up new possibilities for the 3D reconstruction of samples, for example in combination with single plane imaging.