Progranulin as marker for autoimmune disorders
Autoantibodies to progranulin in samples from subjects suffering from ANCA-associated and ANCA-negative primary systemic vasculitides as well as in other autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis have been identified. In addition, also progranulin with a specific posttranslational modification and aberrant forms of progranulin in these autoimmune patientshas been found.
A neutralizing effect of anti-progranulin autoantibodies on progranulin plasma levels, which is of particular interest in the light of progranulin’s function as a potent direct inhibitor of TNFR-1&2 has been demonstrated as well as the fact, that the presence of anti-progranulinautoantibodies is significantly associated with active disease.
Further Information: PDF
Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
Phone: +49 (0)681/302-71302
Contact
Dipl.-Kfm. Axel Koch (MBA), Dr. Conny Clausen, Dr. Nicole Comtesse, Dr. Frank Döbrich
Media Contact
All latest news from the category: Technology Offerings
Newest articles
First-of-its-kind study uses remote sensing to monitor plastic debris in rivers and lakes
Remote sensing creates a cost-effective solution to monitoring plastic pollution. A first-of-its-kind study from researchers at the University of Minnesota Twin Cities shows how remote sensing can help monitor and…
Laser-based artificial neuron mimics nerve cell functions at lightning speed
With a processing speed a billion times faster than nature, chip-based laser neuron could help advance AI tasks such as pattern recognition and sequence prediction. Researchers have developed a laser-based…
Optimising the processing of plastic waste
Just one look in the yellow bin reveals a colourful jumble of different types of plastic. However, the purer and more uniform plastic waste is, the easier it is to…