Protein RPS19 for the treatment of inflammatory diseases and cancer
With respect to both structure and function, the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) is a unique mediator of the immune system, whose important role in inflammatory diseases such as septic shock, chronic inflammations and autoimmune diseases such as arthritis, glomerulonephritis, autoimmune encephalitis, and autoimmune diabetes is well known. In this context, the chemotactic effect of MIF on monocytes is an important step of the inflammatory cascade, which is mediated by a binding of MIF to the chemokine receptors CXCR2 and CXCR4.<br>
Our scientific studies now showed for the first time that the ribosomal protein S19 (symbol: RPS19, HGNC ID:10402) is able to inhibit the pro-inflammatory effect of the central mediator of inflammation, the macrophage migration inhibitory factor (MIF), in a receptordependent manner. Further in vitro experiments confirm an interaction of MIF with RPS19.
Further Information: PDF
TransMIT Gesellschaft für Technologietransfer mbH
Phone: +49 (0)641/943 64-12
Contact
Dr. Peter Stumpf
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Future AR/VR controllers could be the palm of your hand
Carnegie Mellon University’s EgoTouch creates simple interfaces for virtual and augmented reality. The new generation of augmented and virtual reality controllers may not just fit in the palm of your…
‘Game changer’ in lithium extraction
Rice researchers develop novel electrochemical reactor. A team of Rice University researchers led by Lisa Biswal and Haotian Wang has developed an innovative electrochemical reactor to extract lithium from natural…
The blue-green sustainable proteins of seaweed
… may soon be on your plate. The protein in sea lettuce, a type of seaweed, is a promising complement to both meat and other current alternative protein sources. Seaweed…