PSA-20 – Polysialic acid for the treatment of age-related macular degeneration and other neurodegenerative diseases

There is no satisfactory therapy to prevent the loss of synapses, axons or neurons in neurodegenerative diseases, such as age-related macular degeneration (AMD), multiple sclerosis and Alzheimer’s disease. Several studies demonstrate that this neuronal damage is partly mediated by proinflammatory cytokines and reactive oxygen species released by tissue macrophages and microglia.

The present invention allows preventing the production of proinflammatory cytokines and reactive oxygen species through the application of low molecular weight polysialic acid PSA-20. In vitro studies showed that PSA-20 prevents the activation of human macrophages and human microglia thereby inhibiting the production of cytotoxic proinflammatory cytokines and reactive oxygen species. It has been shown, that this anti-inflammatory effect is mediated through the human lineage specific receptor Siglec-11.

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