QUANTIFICATION OF MUTATED RAS:RAF COMPLEXES IN VIVO

Strategy to systematically quantify protein complex formation of cancer relevant, full length, and mutated RAS:RAF in vivo. The presented extendable reporter system facilitates the identification of lead molecules which reduce/prevent either directly or allosterically the formation of carcinogenic H-,K-,N-RAS : A-,B-,C-RAF complexes in vivo.

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