Monoclonal antibody: Mouse anti-human / anti-rat beta-arrestin1,2
Scientists at the Georg-August-University produced different monoclonal antibodies directed against beta-arrestin1 and beta-arrestin2 (one reacts specifically with beta-arrestin1 but not beta-arrestin2, the other one with both of them). Arrestins are cytosolic proteins that are involved in G protein-coupled receptor (GPCR) desensitization. Arrestin binding to activated GPCRs phosphorylation dependent and once bound, uncouple the GPCR from the associated heterotrimeric G proteins. There are currently known 4 mammalian isoforms, beta-arrestin1 (arrestin2), beta-arrestin2 (Arrestin3), visual arrestin (Arrestin1), and cone arrestin. The beta-isoforms are ubiquitously expressed and known to interact with acetylcholine and adrenergic receptors.
Further Information: PDF
MBM ScienceBridge GmbH
Phone: (0551) 30724-151
Contact
Dr. Jens-Peter Horst
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Parallel Paths: Understanding Malaria Resistance in Chimpanzees and Humans
The closest relatives of humans adapt genetically to habitats and infections Survival of the Fittest: Genetic Adaptations Uncovered in Chimpanzees Görlitz, 10.01.2025. Chimpanzees have genetic adaptations that help them survive…
You are What You Eat—Stanford Study Links Fiber to Anti-Cancer Gene Modulation
The Fiber Gap: A Growing Concern in American Diets Fiber is well known to be an important part of a healthy diet, yet less than 10% of Americans eat the minimum recommended…
Trust Your Gut—RNA-Protein Discovery for Better Immunity
HIRI researchers uncover control mechanisms of polysaccharide utilization in Bacteroides thetaiotaomicron. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Julius-Maximilians-Universität (JMU) in Würzburg have identified a…